Organ EE, Adamson TC, 3rd, Fronek Z, Calabrese LH, Dollars JM, Markenson JA, Matsumoto AK, Bathon J, Matteson EL, Uramoto KM, Weyand CM, Koopman WJ, Heck LW, Strand V, Diveley JP, Carlo DJ, Nardo CJ, Richieri SP, Brostoff SW: T mobile receptor peptide vaccination in rheumatoid arthritis: a placebo-controlled trial employing a mixture of V3, V14, and V17 peptides. Arthritis Rheum 1998, 41:1919-1929. 63. Nishizuka Y, Sakakura T: Thymus and copy: sex-linked dysgenesia with the gonad after neonatal thymectomy in mice. Science 1969, 166:753-755. 64. Kojima A, Tanaka-Kojima Y, Sakakura T, Nishizuka Y: Avoidance of postthymectomy autoimmune thyroiditis in mice. 1-Oleoyl lysophosphatidic acid Lab Commit 1976, 34:601-605. 65. Itoh M, Takahashi T, Sakaguchi N, Kuniyasu Y, Shimizu J, Otsuka F, Sakaguchi S: Thymus and autoimmunity: manufacture of CD25+CD4+ normally anergic and suppressive T cells like a essential function from the thymus in protecting immunologic self-tolerance. J Immunol 1999, 162:5317-5326. 66. Sakaguchi S, Sakaguchi N, Shimizu J, Yamazaki S, Sakihama T, Itoh PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/11836127 M, Kuniyasu Y, Nomura T, Toda M, Takahashi T: Immunologic tolerance managed by CD25+ CD4+ regulatory T cells: their frequent role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol Rev 2001, 182:18-32. 67. Sakaguchi S, Takahashi T, Yamazaki S, Kuniyasu Y, Itoh M, Sakaguchi N, Shimizu J: Immunologic self tolerance taken care of by T-cell-mediated handle of self-reactive T cells: implications for autoimmunity and tumor immunity. Microbes Infect 2001, three:911-918. 68. McHugh RS, Shevach EM, Thornton AM: Command of organ-specific autoimmunity by immunoregulatory CD4+CD25+ T cells. Microbes Infect 2001, three:919-927. sixty nine. Singh B, Read S, Asseman C, Malmstrom V, Mottet C, Stephens LA, Stepankova R, Tlaskalova H, Powrie F: Handle of intestinal irritation by regulatory T cells. Immunol Rev 2001, 182:190-200. 70. Fehervari Z, Yamaguchi T, Sakaguchi S: The dichotomous function of IL-2: tolerance as opposed to immunity. Traits Immunol 2006, 27:109-111. 71. Charbonnier L-M, Han WGH, Quentin J, Huizinga TWJ, Zwerina J, Toes REM, Jorgensen C, Louis-Plence P: Adoptive transfer of IL-10-secreting CD4+CD49b+ regulatory T cells suppresses ongoing arthritis. J Autoimmun 2010, 34:390-399. 72. Morgan ME, Flierman R, van Duivenvoorde LM, Witteveen HJ, van Ewijk W, van Laar JM, de vries RRP, Toes REM: Powerful therapy of collagen-induced arthritis by adoptive transfer of CD25+ regulatory T cells. Arthritis Rheum 2005, fifty two:2212-2221. seventy three. Tarbell KV, Petit L, Zuo X, Toy P, Luo X, Mqadmi A, Yang H, Suthanthiran M, Mojsov S, Steinman RM: Dendritic cell-expanded, islet-specific CD4+CD25+CD62L+ regulatory T cells restore normoglycemia in diabetic NOD mice. J Exp Med 2007, 204:191-201. 74. Putnam AL, Brusko TM, Lee MR, Liu W, Szot GL, Ghosh T, Atkinson MA, Bluestone JA: Expansion of human regulatory T-cells from individuals with variety 1 diabetic issues. Diabetic issues 2009, fifty eight:652-662. 75. Groux H, O'Garra A, Bigler M, Rouleau M, Antonenko S, de Vries JE, Roncarolo MG: A CD4+ T-cell subset inhibits antigen-specific T-cell responses and stops colitis. Character 1997, 389:737-742. 76. Levings MK, Gregori S, Tresoldi E, Cazzaniga S, Bonini C, Roncarolo MG: Differentiation of Tr1 cells by immature dendritic cells necessitates IL-10 but not CD25+CD4+ Tr cells. Blood 2005, one zero five:1162-1169. 77. Bacchetta R, de Waal Malefijt R, Yssel H, Abrams J, de Vries JE, Spits H, Roncarolo MG: Host-reactive CD4+ and CD8+ T cell clones isolated from the human chimer.